Histological Evaluation of Solution Polyvinylpyrrolidone Collagene Combined with Allograft in Reconstruction Process in Alveolar Implant Therapy
Evaluate bone regeneration and clinical characteristics of the bone and softh tissues with solution collagen polyvinyl-pyrrolidone combined with alografth for implant therapy .
INTRODUCTION:
The collagen-polyvinylpyrrolidone (collagen-PVP) is a fully absorbable material and has demonstrated capability and inducing hemostatic healing. The treatment of fractures with collagen pvp accelerates fracture repair by promoting the replacement of fibrous callus by callus in less time.
Collagen-polyvinylpyrrolidone (collagen-pvp) in lyophilized form by way of dressing; composed of γ-irradiated mixture of type I collagen pepsinizada extracted from pig and low molecular weight polyvinylpyrrolidone, is a fully absorbable material and has demonstrated
hemostatic capacity and inducing healing. Type 1 collagen is a major extracellular matrix protein bone comprises 90% of it and plays an important role in bone repair.
The collagen type I and III, decreases the expression of interleukin 1-B (IL-1B), tumor necrosis factor (TNF-α), derived growth factor (PDGF) and vascular cell adhesion molecule 1 (VCAM-1). Obviously has modulatory effects on the inflammatory process and the process by regulating fibrogenic several molecules important in these processes.
Within its pharmacokinetics can be established that intramuscular collagen, cutaneous or subcutaneous injection is metabolized in the same way as the endogenous collagen, degraded in the extracellular space mainly by interstitial collagenase and degradation peptides are rapidly generated metabolized by enzymes and other enzymes gelatinases nonspecific. Given the source for obtaining collagen characteristically low antigenicity and it is considered a virtually harmless material, except in patients hypersensitive to express it.
For its part, the polyvinylpyrrolidone is an inert polymer that is virtually non-metabolizable mainly excreted in urine (95%) within less than 24 h. Pharmacodynamics within that data are generated in vitro studies suggest that the collagen PVP acts on fibroblasts and macrophages modulating the metabolism of collagen, so that such regulation is involved in the reparative process.
MATERIALS AND METHODS:
The sample included 30 patients of the clinic of periodontics graduate collapses partially edentulous which included both vertical and horizontal, to accept regenerative therapy and implant and were divided into 2 groups) control (15 patients was used demineralized freeze-dried bone collagen membrane + resorbable) experimental (15 patients use demineralized freeze-dried bone collagen polyvinylpyrrolidone + + in solution resorbable collagen membrane).
Biopsies were taken at 4 months of regeneration.
RESULTS:
Clinically demonstrated improved healing and wound closure in patients in the experimental group, in closing the wound showed the experimental group from the 14th day a complete closure of the soft tissues, while in the control group was observed that wound closure in some patients until day 21.
CONCLUSIONS:
Only in a defect ridge was not possible implant placement because of the presence offibro tissue.
Histologically, there was greater amount of bone cells as osteoblasts and osteocytes in the experimental group, which also observed the presence of mature bone.
Showed the presence of tissue and inflammatory tissue fibro, which we checked the immaturity of the tissue at 4 months of the procedure performed in the control group..