Clinical Application of Parameteric X-Ray in Diagnostic Imaging: Preliminary Study

Kaneda, Takashi

Clinical Application of Parameteric X-Ray in Diagnostic Imaging: Preliminary Study

Takashi Kaneda DDS, PhD, Department of Radiology, Nihon University School of Dentistry at Matsudo, Matsudo, Japan

Yusuke Kawashima DDS, Department of Radiology, Nihon University School of Dentistry at Matsudo, Matsudo, Japan

Yusuke Sasaki DDS, PhD, Department of Radiology, Nihon University School of Dentistry at Matsudo, Matsudo, Japan

Masaaki Suemitsu DDS, PhD, Department of Oral Pathology, Nihon University School of Dentistry at Matsudo, Matsudo, Japan

Hiroyuki Okada DDS, PhD, Department of Histology, Cytology and Developmental Anatomy, Nihon University School of Dentistry at Matsudo, Matsudo, Japan

Yasushi Hayakawa PhD, Laboratory for Electron Beam Research and Application (LEBRA), Institute of Quantum Science, Funabashi Campus of College of Science and Technology, Nihon University, Funabashi, Japan

Toshiro Sakae PhD, Department of Histology, Cytology and Developmental Anatomy, Nihon University School of Dentistry at Matsudo, Matsudo, Japan

Hirotaka Muraoka dds, Department of Radiology, Nihon University School of Dentistry at Matsudo, Matsudo, Japan

Naohisa Hirahara DDS, Department of Radiology, Nihon University School of Dentistry at Matsudo, Matsudo, Japan

Parametric radiation based X-ray (PXR), one of the pioneering studies using accelerator, is studied and expected for a kind of new X-ray source.

The purpose of this study was to evaluate the potential of LEBRA- parameteric X-ray as a new X-ray source for diagnostic imaging. Preliminary clinical application study.

The subject was a dog mandibular tissue with malignant melanoma. Simple X-ray images were taken with LEBRA-PXR in several wavelengths (12keV, 15keV, 18keV, 21keV, 24keV, 27keV, 30keV,). An energy subtracted image was generated with the image with the lowest wavelength PXR and the image with the shortest wavelength PXR. As a control, an image was taken with conventional X-ray (40kV, 125mA, 40msec; effective energy 21keV).

Simple X-ray images were taken with LEBRA-PXR, an energy subtracted image and conventional X-ray images were compared with the histopathological stained images.

Compared to conventional X-ray, LEBRA-PXR images showed contrast related to different wavelengths, reflecting histological differences between tissues.

Energy subtraction imaging with LEBRA-PXR offered more soft tissue and osteolytic bony image informations with regard to morphology and structure. Comparing histological findings, malignant tumor images with LEBRA-PXR revealed more clearly than that of conventional X-ray image.

Using LEBRA-PXR, nearly perfect monochromatic X-ray source imaging, the images of malignant tumor displayed different contrasts from conventional X-ray. LEBRA-PXR produce a useful diagnostic imaging tool as a new X-ray source.

References

1. Sakae T, Hayakawa Y, Tkahashi Y, et al. A Preliminary Study on Low-dose X-ray Imaging Using Parametric X-ray. J Hard Tissue Biol 2011;20:31-36

2. Hayakawa Y, Hayakawa K, Inagaki M, et al. Dependence of PXR beam performance on the operation of the pulsed electron linac. Nucl Instr in Meth B 2008 ;266 :3758-3769