Management of Squamous Cell Carcinoma of the Mandibular Gingiva

Kenji Nakamori DDS, PhD, Department of Oral and Maxillofacial Surgery, University of Toyama, Toyama, Japan
Makoto Noguchi DDS, PhD, Department of Oral and Maxillofacial Surgery, University of Toyama, Toyama, Japan
Kei Tomoihara DDS, PhD, Department of Oral and Maxillofacial Surgery, University of Toyama, Toyama, Japan
Shuichi Imaue DDS, Department of Oral and Maxillofacial Surgery, University of Toyama, Toyama, Japan
Rie Takei DDS, Department of Oral and Maxillofacial Surgery, University of Toyama, Toyama, Japan
Wataru Heshiki DDS, Department of Oral and Maxillofacial Surgery, University of Toyama, Toyama, Japan
Hidetake Tachinami DDS, Department of Oral and Maxillofacial Surgery, University of Toyama, Toyama, Japan
The purpose of this study was to clarify the validity of treatment modalities for management of squamous cell carcinoma (SCC) in the mandibular gingiva.

We analyzed 28 patients diagnosed with SCC of the mandibular gingiva treated at our hospital from April 2007 to December 2013.

Four patients were diagnosed with stage I carcinoma, 10 with stage II, 7 with stage III, 7 with stage IVA, and 1 with stage IVB. Eleven patients underwent surgical treatment, while 12 underwent induction chemotherapy (ICT) along with surgery. Patients with early stage carcinomas were mainly treated with surgery alone, (3 patients with stage I, 3 with stage II, 3 with stage III, and 1 with stage IVA), whereas those with stage II to IVA underwent ICT along with surgery. Concurrent chemoradiotherapy plus surgery was performed in 4 advanced cases (stage IVA), and 1 case was treated only with chemoradiotherapy (stage IVB). Local recurrence was observed in 6 patients. In 3 patients, recurrence was observed at the peripheral superficial site, and they were treated with additional surgical management. However, the other 3 patients succumbed to cancer. Regional metastases were observed in 2 patients, while 1 died of cancer. These result suggesting the clinical usefulness of our treatment strategy.

References

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