Influence of Diagnosis to Treatment Interval in the Prognosis of Oral Squamous Cell Carcinoma
Hitoshi Yoshimoto DDS, PhD, 2nd Department of Oral and Maxillofacial Surgery, OSAKA DENTAL UNIVERSITY, OSAKA, Japan
Masahiro Nakajima PhD, 2nd Department of Oral and Maxillofacial Surgery, OSAKA DENTAL UNIVERSITY, OSAKA, Japan
Yuichi Onishi PhD, 2nd Department of Oral and Maxillofacial Surgery, OSAKA DENTAL UNIVERSITY, OSAKA, Japan
Hirohito Kubo DDS, PhD, 2nd Department of Oral and Maxillofacial Surgery, OSAKA DENTAL UNIVERSITY, OSAKA, Japan
Hideya Haeniwa DDS, PhD, Second Department of Oral and Maxillofacial Surgery, Osaka Dental University, OSAKA, Japan
Motohiro Gotoh DDS, PhD, 2nd Department of Oral and Maxillofacial Surgery, OSAKA DENTAL UNIVERSITY, OSAKA, Japan
Katsuko Horii DDS, 2nd Department of Oral and Maxillofacial Surgery, OSAKA DENTAL UNIVERSITY, OSAKA, Japan
Yuichi Shoju DDS, PhD, 2nd Department of Oral and Maxillofacial Surgery, OSAKA DENTAL UNIVERSITY, OSAKA, Japan
Kenji Kakudo DDS, PhD, Second Department of Oral and Maxillofacial Surgery, OSAKA DENTAL UNIVERSITY, OSAKA, Japan
Background: Surgery for oral squamous cell carcinoma ( OSCC ) is often delayed due to variety reason. Time delay prior to treatment can lead to increased risk of clinical progression, which could compromise the prognosis. However, impact of delayed surgery is not clear. We aimed to determine the impact of the delay from cancer diagnosis to potentially curative surgery on survival in patients with T1, T2 OSCC.
Methods:Cohort study based on representative sample of patients ( n=132 ) with T1,2 OSCC who underwent surgery between 1999 and 2009 at the Osaka dental university . Diagnosis to treatment interval was calculated from the date of diagnosis to the surgical resection date and categorized into four groups, group A: 0-26 days, group B: 27-36 days, group C: 37-46 days and group D: more than 47 days. The 5-year survival rate were assessed via Kaplan-Meier survival analyses.
RESULT: Patients averaged 68 years of age ( 29 to 89 ), 65 males and 67 female. Median follow-up was 65 months ( 7 to 160 months ). Sixty three patients had tongue carcinoma, followed by twenty nine patients with maxillary carcinoma. The rest includes twenty one alveolar ridge carcinoma, ten floor of mouth carcinoma, four cheek carcinoma, five hard palate carcinoma The median time diagnosis to treatment interval was 26 days ( 10 to 161 days ). The 5-year survival rate of all patients was 92 %. The 5-year survival rate of group A, B, C and D were 98, 97, 82 and 82%, respectively. There were significant differences in 5-year survival rate in group A, B and group C, D.
CONCLUSION: A prolonged Diagnosis to treatment interval appear to adversely affect outcome in this study.
