Three Dimensional Analysis of ABM/ P-15 with Sodium Hyaluronate Carrier In Sinus Augmentation

PepGen P-15 Putty is anorganic bovine matrix coupled with a synthetic cell binding peptide (ABM/P-15) suspended in a sodium hyaluronate carrier. The P-15 portion has a similar structure to, and subsequently exhibits similar properties of, the cell-binding region of type I collagen.  “Purpose:” To evaluate ABM/P-15 Putty (DENTSPLY Friadent CeraMed, Lakewood, CO) as the sole graft material in sinus augmentation for future reconstruction with root form dental implants.  “Patients & Methods:” Ten patients were enrolled in a clinical trial in which sinus augmentations were performed on each patient using ABM/P-15 Putty.  Bone core biopsies were harvested using a 2.0mm diameter trephine bur at 8 and 16 weeks, followed by immediate implant placement. Twenty collected bone cores were evaluated histologically and using Micro-CT to examine the bone at the grafted sites.  “Results:” The student t-test showed significant increase (P<0.05) in the bone mineral density (BMD) at 8 weeks (0.7 ± 0.13 gm/cm³) and 16 weeks (0.97 ± 0.08 gm/cm³) in the ABM/P-15 graft compared to the native residual  (control) bone (0.04 ± 0.02 gm/cm³). There was no significant difference (P>0.05) in the percent bone volume (PBV) at the two time intervals (PBV 21.14 ± 4.56 at 8 weeks, and 26.33 ± 5.6 at 16 weeks). The average increase in bone height at 16 weeks was 10.55 ± 0.53 mm. Micro-CT images and histologic sections demonstrated dense graft particles surrounded by vital bone in an interconnected trabecular pattern.  Three-year clinical and radiographic follow-up revealed all implants successfully integrated. “Conclusion:” PepGen P-15 Putty is an osteoconductive graft material capable of conducting new bone formation and successfully supports osseointegration of dental implants when used for sinus augmentation.

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